Japanese Pharmacology & Therapeutics（JPT）
Vol. 27 No. 4 1999
* With abstract in English
▲A report on SMO for clinical research in USA
K. Ninomiya, et al.
Jpn Pharmacol Ther 1999 27(4) 513-23
Cardiovascular effects of a histamine H2-receptor antagonist pibutidine hydrochloride and its metabolite M-8
Y. Isobe, et al.
Jpn Pharmacol Ther 1999 27(4) 529-42
General pharmacological studies of a histamine H2-receptor antagonist pibutidine hydrochloride and its metabolites, M-5 and M-8
Y. Isobe, et al.
Jpn Pharmacol Ther 1999 27(4) 543-61
Disposition of pibutidine hydrochloride, 3-amino-4-［［(Z)-4-［［4-(piperidinomethyl)-2-pyridyl］oxy］-2-butenyl］amino］-3-cyclobutene-1, 2-dione monohydrochloride (IT-066)(1)
―Absorption, distribution and excretion after single administration to rats―
M. Arai, et al.
Jpn Pharmacol Ther 1999 27(4) 563-85
Disposition of pibutidine hydrochloride, 3-amino-4-［［(Z)-4-［［4-(piperidinomethyl)-2-pyridyl］oxy］-2-butenyl］amino］-3-cyclobutene-1, 2-dione monohydrochloride (IT-066)(2)
―Transfer into fetus and milk after single oral administration, and absorption, distribution and excretion after repeated oral administration to rats―
M. Arai, et al.
Jpn Pharmacol Ther 1999 27(4) 587-97*
Disposition of pibutidine hydrochloride, 3-amino-4-［［(Z)-4-［［4-(piperidinomethyl)-2-pyridyl］oxy］-2-butenyl］amino］-3-cyclobutene-1, 2-dione monohydrochloride (IT-066)(3)
―Absorption and excretion after single administration to dogs―
M. Arai, et al.
Jpn Pharmacol Ther 1999 27(4) 599-604*
Disposition of pibutidine hydrochloride, 3-amino-4-［［(Z)-4-［［4-(piperidinomethyl)-2-pyridyl］oxy］-2-butenyl］amino］-3-cyclobutene-1, 2-dione monohydrochloride (IT-066)(4)
―Metabolism in dogs―
M. Arai, et al.
Jpn Pharmacol Ther 1999 27(4) 605-18*
Disposition of pibutidine hydrochloride, 3-amino-4-［［(Z)-4-［［4-(piperidinomethyl)-2-pyridyl］oxy］-2-butenyl］amino］-3-cyclobutene-1, 2-dione monohydrochloride (IT-066)(5)
―Metabolism in rats―
M. Arai, et al.
Jpn Pharmacol Ther 1999 27(4) 619-42*
Disposition of pibutidine hydrochloride, 3-amino-4-［［(Z)-4-［［4-(piperidinomethyl)-2-pyridyl］oxy］-2-butenyl］amino］-3-cyclobutene-1, 2-dione monohydrochloride (IT-066)(6)
―Absorption, distribution and excretion after single administration of 14C-IT-066(C) in rats―
M. Arai, et al.
Jpn Pharmacol Ther 1999 27(4) 643-50*
Disposition of pibutidine hydrochloride, 3-amino-4-［［(Z)-4-［［4-(piperidinomethyl)-2-pyridyl］oxy］-2-butenyl］amino］-3-cyclobutene-1, 2-dione monohydrochloride (IT-066)(7)
―Metabolism of 14C-IT-066(C) in rats―
M. Arai, et al.
Jpn Pharmacol Ther 1999 27(4) 651-69*
Effect of glycyrrhizin on monoamine dynamics in the rat brain
T. Egashira, et al.
Jpn Pharmacol Ther 1999 27(4) 671-5*
A newly developed wound dressing made of alginate fiber containing zeolite substituted by silver
and zinc
―Fundamental study―
K. Miyasato, et al.
Jpn Pharmacol Ther 1999 27(4) 677-703*
Effect of proton pump inhibitor, rabeprazole, on gastric acid secretion
―Inhibitory effect on gastrin-stimulated acid secretion by 10mg dosing of rabeprazole in healthy male volunteers
A. Iwasaki, et al.
Jpn Pharmacol Ther 1999 27(4) 705-13*
Development of newly formulated antimicrobial wound dressing (Non woven sheet of Ag-ZN Zeolite impregnated Ca alginate fiber)
―A multi-centric clinical study―
M. Anze, et al.
Jpn Pharmacol Ther 1999 27(4) 715-45*
Economic evaluation of cholesterol-lowering therapy for hypercholesterolemia, cost-effectiveness of HMG-CoA reductase inhibitors
T. Katayama, et al.
Jpn Pharmacol Ther 1999 27(4) 747-58