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Japanese Pharmacology & Therapeutics(JPT)

Vol. 27 No. 4 1999

* With abstract in English


▲A report on SMO for clinical research in USA

K. Ninomiya, et al.

Jpn Pharmacol Ther 1999 27(4) 513-23

■ PHARMACOLOGY AND CLINICAL PHARMACOLOGY

Cardiovascular effects of a histamine H2-receptor antagonist pibutidine hydrochloride and its metabolite M-8

Y. Isobe, et al.

Jpn Pharmacol Ther 1999 27(4) 529-42


General pharmacological studies of a histamine H2-receptor antagonist pibutidine hydrochloride and its metabolites, M-5 and M-8

Y. Isobe, et al.

Jpn Pharmacol Ther 1999 27(4) 543-61


Disposition of pibutidine hydrochloride, 3-amino-4-[[(Z)-4-[[4-(piperidinomethyl)-2-pyridyl]oxy]-2-butenyl]amino]-3-cyclobutene-1, 2-dione monohydrochloride (IT-066)(1)
―Absorption, distribution and excretion after single administration to rats―

M. Arai, et al.

Jpn Pharmacol Ther 1999 27(4) 563-85


Disposition of pibutidine hydrochloride, 3-amino-4-[[(Z)-4-[[4-(piperidinomethyl)-2-pyridyl]oxy]-2-butenyl]amino]-3-cyclobutene-1, 2-dione monohydrochloride (IT-066)(2)
―Transfer into fetus and milk after single oral administration, and absorption, distribution and excretion after repeated oral administration to rats―

M. Arai, et al.

Jpn Pharmacol Ther 1999 27(4) 587-97*


Disposition of pibutidine hydrochloride, 3-amino-4-[[(Z)-4-[[4-(piperidinomethyl)-2-pyridyl]oxy]-2-butenyl]amino]-3-cyclobutene-1, 2-dione monohydrochloride (IT-066)(3)
―Absorption and excretion after single administration to dogs―

M. Arai, et al.

Jpn Pharmacol Ther 1999 27(4) 599-604*


Disposition of pibutidine hydrochloride, 3-amino-4-[[(Z)-4-[[4-(piperidinomethyl)-2-pyridyl]oxy]-2-butenyl]amino]-3-cyclobutene-1, 2-dione monohydrochloride (IT-066)(4)
―Metabolism in dogs―

M. Arai, et al.

Jpn Pharmacol Ther 1999 27(4) 605-18*


Disposition of pibutidine hydrochloride, 3-amino-4-[[(Z)-4-[[4-(piperidinomethyl)-2-pyridyl]oxy]-2-butenyl]amino]-3-cyclobutene-1, 2-dione monohydrochloride (IT-066)(5)
―Metabolism in rats―

M. Arai, et al.

Jpn Pharmacol Ther 1999 27(4) 619-42*


Disposition of pibutidine hydrochloride, 3-amino-4-[[(Z)-4-[[4-(piperidinomethyl)-2-pyridyl]oxy]-2-butenyl]amino]-3-cyclobutene-1, 2-dione monohydrochloride (IT-066)(6)
―Absorption, distribution and excretion after single administration of 14C-IT-066(C) in rats―

M. Arai, et al.

Jpn Pharmacol Ther 1999 27(4) 643-50*


Disposition of pibutidine hydrochloride, 3-amino-4-[[(Z)-4-[[4-(piperidinomethyl)-2-pyridyl]oxy]-2-butenyl]amino]-3-cyclobutene-1, 2-dione monohydrochloride (IT-066)(7)
―Metabolism of 14C-IT-066(C) in rats―

M. Arai, et al.

Jpn Pharmacol Ther 1999 27(4) 651-69*


Effect of glycyrrhizin on monoamine dynamics in the rat brain

T. Egashira, et al.

Jpn Pharmacol Ther 1999 27(4) 671-5*


A newly developed wound dressing made of alginate fiber containing zeolite substituted by silver and zinc
―Fundamental study―

K. Miyasato, et al.

Jpn Pharmacol Ther 1999 27(4) 677-703*


Effect of proton pump inhibitor, rabeprazole, on gastric acid secretion
―Inhibitory effect on gastrin-stimulated acid secretion by 10mg dosing of rabeprazole in healthy male volunteers

A. Iwasaki, et al.

Jpn Pharmacol Ther 1999 27(4) 705-13*

■ THERAPEUTICS

Development of newly formulated antimicrobial wound dressing (Non woven sheet of Ag-ZN Zeolite impregnated Ca alginate fiber)
―A multi-centric clinical study―

M. Anze, et al.

Jpn Pharmacol Ther 1999 27(4) 715-45*

■ RESEARCH

Economic evaluation of cholesterol-lowering therapy for hypercholesterolemia, cost-effectiveness of HMG-CoA reductase inhibitors

T. Katayama, et al.

Jpn Pharmacol Ther 1999 27(4) 747-58