Japanese Pharmacology & Therapeutics（JPT）
Vol. 46 No. 4 2018
What consequence is anticipated by the emergence of a novel SPPARMα agent developed so as to achieve an improved safety/efficacy balance?
－Potential to be confirmed and health economics evaluation for cardiovascular disease prevention－
M. Anai, et al.
Jpn Pharmacol Ther 2018 46（4）471-80
Safety and efficacy of teneligliptin, a dipeptidyl peptidase-4 inhibitor, in monotherapy and in combination therapy with antihyperglycemic agents in patients with type 2 diabetes mellitus
－An interim analysis of post-marketing surveillance, RUBY－
T. Kadowaki, et al.
Jpn Pharmacol Ther 2018 46（4）481-98
Safety and efficacy of canagliflozin, a sodium-glucose co-transporter 2 inhibitor, as monotherapy and in combination with antidiabetic agents in patients with type 2 diabetes mellitus
－An interim analysis of post-marketing surveillance (SAPPHIRE)－
N. Inagaki, et al.
Jpn Pharmacol Ther 2018 46（4）499-519
Safety evaluation of a food containing salmon nasal cartilage-derived proteoglycan (Proteoglycan F)
－A single-dose toxicity study in rats－
T. Takahashi, et al.
Jpn Pharmacol Ther 2018 46（4）523-7
Antihypertensive effect of the casein-derived peptide Met-Lys-Pro in individuals with high-normal blood pressure or grade 1 hypertension
－A randomized, double-blind, placebo-controlled, parallel-group trial－
N. Yuda, et al.
Jpn Pharmacol Ther 2018 46（4）529-37
Effects of fermented tea leaves made by tea-rolling processing of loquat leaves and third crop green tea leaves on visceral fat
―A randomized, double-blind, placebo-controlled, parallel-group comparative study－
K. Tanaka, et al.
Jpn Pharmacol Ther 2018 46（4）539-47
Effect of chocolate containing Lactobacillus brevis NTT001 on intestinal environment
－A randomized, double-blind, placebo-controlled, crossover trial－
H. Higuchi, et al.
Jpn Pharmacol Ther 2018 46（4）549-60
Effects of Sanchi ginseng extract on the sexual function in Japanese men
－A randomized, double-blind, placebo-controlled, parallel-group trial－
S. Yamashita, et al.
Jpn Pharmacol Ther 2018 46（4）561-80
Effects of hydrogen-rich water on attenuating fatigue induced by daily activities or mental tasks
K. Watanabe, et al.
Jpn Pharmacol Ther 2018 46（4）581-97
Impact of cocoa ingestion on warm-up effects among healthy elderly persons
－A placebo-controlled, double-blind, crossover, comparative trial－
T. Imada, et al.
Jpn Pharmacol Ther 2018 46（4）599-607
Effect of cocoa on flexibility after a warm-up
－A placebo-controlled, double-blind, crossover, comparative study－
A. Ohkubo, et al.
Jpn Pharmacol Ther 2018 46（4）609-18
Japanese sake yeast improves human fatigue and vitality
－A double-blind, randomized placebo-controlled clinical cross-over trial－
Y. Nagamori, et al.
Jpn Pharmacol Ther 2018 46（4）619-25
Beneficial effect of enzymolyzed honeybee larvae powder on tinnitus symptoms
－A randomized, single-blind, placebo-controlled, parallel-group, comparison study－
A. Ohkuma, et al．
Jpn Pharmacol Ther 2018 46（4）627-37