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Japanese Pharmacology & Therapeutics (JPT)

Vol. 39 Suppl. 1 2011

Clinical Evaluation of C.E.R.A.(Continuous Eythropoietin Receptor Activator), a Novel Long-acting Erythropoiesis Stimulating Agent

【Hemodialysis】

A dose-finding study of C.E.R.A.(continuous erythropoietin receptor activator)in renal anemia patients on hemodialysis
―A randomized double-blind comparative study―

E. Kinugasa, et al.

Jpn Pharmacol Ther 2010 39(s1) s9-19


Clinical efficacies of C.E.R.A.(continuous erythropoietin receptor activator)administered intravenously to epoetin (EPO)naïe renal anemia patients on hemodialysis
―Phase III study―

Y. Watanabe, et al.

Jpn Pharmacol Ther 2011 39(s1) s21-30


Switching and maintenance study of intravenous C.E.R.A.(continuous erythropoietin receptor activator)after switching from rHuEPO in hemodialysis patients

Y. Tsuruta, et al.

Jpn Pharmacol Ther 2010 39(s1) s31-42


【Chronic kidney disease not on dialysis】

Dose-finding and long-term studies with C.E.R.A.(continuous erythropoietin receptor activator)administered subcutaneously(SC)or intravenously(IV)in Japanese patients with chronic kidney disease(CKD)not on dialysis

K. Hori, et al.

Jpn Pharmacol Ther 2010 39(s1) s43-54


Effect of hemoglobin(Hb)maintenance of subcutaneous(SC)or intravenous(IV)C.E.R.A.(continuous erythropoietin receptor activator)in chronic kidney disease(CKD)patients not on dialysis

Y. Yuzawa, et al.

Jpn Pharmacol Ther 2011 39(s1) s55-68


【Peritoneal dialysis】

Effect of haemoglobin(Hb)maintenance of subcutaneous(SC)or intravenous(IV)C.E.R.A.(continuous erythropoietin receptor activator)in renal anemia patients on peritoneal dialysis

M. Hiramatsu, et al.

Jpn Pharmacol Ther 2011 39(s1) s69-78


【APPENDIX】

Pharmacokinetic and pharmacodynamic characteristics of C.E.R.A., a novel continuous erythropoietin receptor activator
─Results of pre-clinical studies─

M. Tamura, et al.

Jpn Pharmacol Ther 2011 39(s1) s249-58


A phase I clinical study of Ro50-3821
―A single subcutaneous dose study―

T. Tanaka, et al.

Jpn Pharmacol Ther 2011 39(s1) s1145-57


Pharmacokinetic properties of C.E.R.A.(continuous erythropoietin receptor activator)in Japanese chronic kidney disease patients not on dialysis

T. Naruse, et al.

Jpn Pharmacol Ther 2011 39(s1) s1159-74


Pharmacokinetics of C.E.R.A.(continuous erythropoietin receptor activator)in Japanese chronic kidney disease patients on dialysis

T. Hayashi, et al.

Jpn Pharmacol Ther 2010 38(s1) s1175-90