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Japanese Pharmacology & Therapeutics(JPT)

Vol. 32 Suppl. 2 2004

The Record of the Twelfth Meeting of the Japanese Study Group for the Pathophysiology of the Liver in Chiba 2004

Opening Remarks

H. Kawasaki

Jpn Pharmacol Ther 2004 32(s2) s95


Association between insun resistance, hepatic iron accumulation, and hepatic steatosis in hepatitis C

Y. Sumida, et al.

Jpn Pharmacol Ther 2004 32(s2) s101


Pathophysiology of nonalcoholic steatohepatitis(NASH)
―Relation to adipocytokine and advanced glycation end products―

H. Hyogo, et al.

Jpn Pharmacol Ther 2004 32(s2) s107


Plasma levels of ADAMTS13 in liver diseases
―With special reference to alcoholic hepatitis―

M. Uemura, et al.

Jpn Pharmacol Ther 2004 32(s2) s111 


【Discussion 1~3】

Jpn Pharmacol Ther 2004 32(s2) s115


Cerebral hemodynamics in the patients with fulminant hepatitis

M. Kawakami, et al.

Jpn Pharmacol Ther 2004 32(s2) s117


The influence of radiofrequency ablation on liver parenchymal functionin in patients with hepatocellular carcinoma
―The alteration of serum cytokine and the effect of branched-chain amino acids―

M. Koda, et al. 

Jpn Pharmacol Ther 2004 32(s2) s121


【Discussion 4~5】 

Jpn Pharmacol Ther 2004 32(s2) s127


Immediate increase of portal pressure, reflecting sinusoidal shear stress, accelerated liver regeneration through increased production of IL-6 and HGF in small-for-size graft

T. Oyama, et al.

Jpn Pharmacol Ther 2004 32(s2) s129


The association of MMP-1, 3 and-9 genotypes with the prognosis of HCV-related hepatocellular carcinoma patients

K. Okamoto, et al. 

Jpn Pharmacol Ther 2004 32(s2) s137


Effects of angiotensin II on the expression of MCP-1 in hepatic stellate cell line LI90

K. Kanno, et al. 

Jpn Pharmacol Ther 2004 32(s2) s143


【Discussion 7~9】 

Jpn Pharmacol Ther 2004 32(s2) s147


Rho regulates hepatic sinusoidal endothelial fenestral actin cytoskeleton

H. Yokomori, et al.

Jpn Pharmacol Ther 2004 32(s2) s149


Endogenous prostaglandins plays a role in concanavalin A-induced liver injury in mice

S. Okamoto, et al.

Jpn Pharmacol Ther 2004 32(s2) s151


Immune tolerance on the liver injury is induced by repeated intravenous injection with concanavalin A in mice

Y. Tamaki, et al.

Jpn Pharmacol Ther 2004 32(s2) s155


Nitric Oxide, induced in the rat liver, improves the glutathion depletion of acetaminophen-caused hepatic injury

T. Asama, et al. 

Jpn Pharmacol Ther 2004 32(s2) s161


【Discussion 11~13】 

Jpn Pharmacol Ther 2004 32(s2) s165


Urtra fast laser activated photodynamic therapy for neovascularization

K. Awazu, et al.

Jpn Pharmacol Ther 2004 32(s2) s167


Prostaglandin E1 ameliorates hyperbilirubinemia with liver failure

S. Nishimura, et al.

Jpn Pharmacol Ther 2004 32(s2) s173


Bilirubin UDP-glucuronosyltransferase(UGT1A1)polymorphism(G71R) and β-estratiol glucuronidation

Y. Maruo, et al. 

Jpn Pharmacol Ther 2004 32(s2) s179


Novel UDP-glucuronosyltransferase(UGT1A3)polymorphisms with varying activity

M. Iwai, et al.

Jpn Pharmacol Ther 2004 32(s2) s183


【Discussion 14~17】

Jpn Pharmacol Ther 2004 32(s2) s189


The mechanism of a clinically relevant drug-drug interaction between cerivastatin and gemfibrozil

Y. Shitara, et al. 

Jpn Pharmacol Ther 2004 32(s2) s193


The involvement of OATP2 and OATP8 transporters in the hepatic uptake of fexofenadine

M. Shimizu, et al.

Jpn Pharmacol Ther 2004 32(s2) s201


Role of liver-specific organic anion transporter-2 in cancer cell lines

H. Oshio, et al.

Jpn Pharmacol Ther 2004 32(s2) s205


【Discussion 18~20】

Jpn Pharmacol Ther 2004 32(s2) s207


Effect of colchicine on the maximum biliary excretion of organic anions and cations

M. Takayanagi, et al.

Jpn Pharmacol Ther 2004 32(s2) s211


Biliary excretion mechanism of fexofenadine, a H1 receptor antagonist

H. Tahara, et al.

Jpn Pharmacol Ther 2004 32(s2) s213


Effect of deletion or point mutation on the polarized expression of human BCRP/ABCG2

T. Takada, et al.

Jpn Pharmacol Ther 2004 32(s2) s219


Functional characterization of MRP4

H. Kusuhara, et al.

Jpn Pharmacol Ther 2004 32(s2) s223


【Discussion 21~24】 

Jpn Pharmacol Ther 2004 32(s2) s229


Investigation of the contribution of transporters expressed in human canalicular membrane to biliary excretion using double-transfected MDCK II cell lines

S. Matsushima, et al.

Jpn Pharmacol Ther 2004 32(s2) s233


Construction of the in vivo evaluation system of human MRP2 using EHBR

M. Hirouchi, et al.

Jpn Pharmacol Ther 2004 32(s2) s239


Suppression of mouse Mrp2 gene in vitro using RNA interference(RNAi)T.

Watanabe, et al.

Jpn Pharmacol Ther 2004 32(s2) s243


Mrp2 is involved in benzylpenicillin-induced choleresis

K. Ito, et al.

Jpn Pharmacol Ther 2004 32(s2) s247 


【Discussion 25~28】

Jpn Pharmacol Ther 2004 32(s2) s253


Closing Remarks

Y. Sugiyama

Jpn Pharmacol Ther 2004 32(s2) s257