Objectives@Coffee contains several polyphenols, the
majority of which are chlorogenic acids. Several components of the polyphenols
have been shown to have the visceral fat-reducing effects. In this study, we evaluated
the effect of the continuous consumption of coffee on body fat, particularly abdominal
Methods@A double-blind, randomized, placebo-controlled intervention study was conducted on Japanese adults with a BMI of 25 to30 kg/m2 and an abdominal visceral fat area of 80 to170 cm2. During 12 weeks of the test beverage ingestion period, the subjects ingested either active or placebo beverageichlorogenic acids contents per 185 g coffeeF297 mg for active, 2 mg for placebojdaily.
Results@A total of 125 participants who met the inclusion criteria at the screeningiconducted at week|4jwere allocated to either of the two beverage groups. Data were analyzed using per-protocol analysis set of 109 subjectsiactive groupGn53, placebo groupGn56j. After 12 weeks of beverage consumption, changes from week-0 valuesiactive vs. placebo, mean}standard errorjin visceral fat areai|4.4}2.1 vs. 3.6}2.3 cm2j, waist circumferencei|1.8}0.2 vs. 0.0}0.2 cmj, and BMIi|0.6}0.1 vs. |0.1}0.1 kg/m2jwere greater in the active group than in the placebo group. No serious adverse events or clinically relevant abnormal changes in the blood and urine parameters were observed with both groups.
Conclusions@These findings suggested that continuous consumption of coffee chlorogenic acids safely reduces body fat, particularly the abdominal fat including visceral fat.