Objectives To evaluate the efficacy of oral
NATTOKINASE (NK) in the prevention of stroke progression Death in patients
of acute ischaemic stroke. To measure the incidence of adverse drug events
with oral NK.
Method Prospective Multicenter Proof?of?concept Open Pilot
Study
Results 5 patients showed favorable response according to
NIHSS scale, 11 patients according to MRS scale and 8 patients according
to BI scale on day 90. Thrombolysis related parameters such as bleeding
time at day 7, Clotting time at day 2 and day 7, PT at day 7, APTT at
day 2, D dimer at day 2 and day 7 are significant different(p<0.05).
Increase PT, APTT and FDP are suggestive of good fibrinolytic action of
NK. Failure of this to translate in to obvious clinical bleeding is suggestive
of a good balanced fibrinolytic effect. The overall efficacy data suggests
that NK, in none of the patients studied, led to a progression of the
underlying stroke, although the time taken for reversal of stroke did
vary across the subjects chosen. A beneficial effect may be demonstrated,
however a further larger comparative study will be necessary under similar
conditions.