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Japanese Pharmacology & Therapeutics(JPT)

Vol.27 Suppl.4 1999

■New Histamine H2-Receptor Antagonist Pibutidine Hydrochloride

Phase 1 clinical study of pibutidine hydrochride

J. Azuma, et al.

Jpn Pharmacol Ther 1999 27(Suppl.4) s973-90


Clinical study of pibutidine hydrochloride(IT-066)on peptic ulcer
-Early dose finding by open study-

K. Kobayashi, et al.

Jpn Pharmacol Ther 1999 27(Suppl.4) s991-1008


Does finding study of pibutidine hydrochloride on peptic ulcer

K. Kobayashi, et al.

Jpn Pharmacol Ther 1999 27(Suppl.4) s1009-35


Clinical study of pibutidine hydrochloride(IT-066)on peptic ulcer
-A multicenter double-blind comparative study with famotidine-

K. Kobayashi, et al.

Jpn Pharmacol Ther 1999 27(Suppl.4) s1037-75


Clinical effect of pibutidine hydrochloride on recurrent ulcer after gastric surgery

T. Aoki, et al.

Jpn Pharmacol Ther 1999 27(Suppl.4) s1077-91


Clinical effect of pibutidine hydrochloride on endocrine function and healing in patients with gastric ulcer

T. Misawa, et al.

Jpn Pharmacol Ther 1999 27(Suppl.4) s1093-13


Clinical evaluation of pibutidine hydrochloride on reflux esophagitis
-Comparison of 20mg daily and 40mg daily-

T. Sekiguchi, et al.

Jpn Pharmacol Ther 1999 27(Suppl.4) s1115-26


Effect of IT-066(pibutidine hydrochloride) on gastric acid secretion(first report)
-Dose finding with 24 hours gastric juice-

M. Tada, et al.

Jpn Pharmacol Ther 1999 27(Suppl.4) s1127-35


Effect of IT-066(pibutidine hydrochloride) on gastric acid secretion(second report)
-Comparative study on UID evening dose and BID evening and morning dose with 24 hours gastric juice-

M. Tada, et al.

Jpn Pharmacol Ther 1999 27(Suppl.4) s1137-47


Acid suppression profile of pibutidine hydrochloride with 24-hour intragastric pH monitoring
-Comparison of treatment 40mg once daily and 20mg twice daily-

S. Asaki, et al.

Jpn Pharmacol Ther 1999 27(Suppl.4) s1149-55