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Japanese Pharmacology & Therapeutics(JPT)

Vol.27 Suppl.3 1999

*With abstract in English  **In English

■The Record of the Sixth Meeting of the Japanese Study Group for the Pathophysiology of the Liver '98

Opening Remarks

T. Namihisa

Jpn Pharmacol Ther 1999 27(Suppl.3) s769


1.Significance of laparoscopic findings for evaluating clinical features in patients with idiopathic portal hypertension

M. Uemura, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s777-81


2.What is PET image using C15O2 inhalation steady state method?
-Association with H215O bolus injection dynamic PET study-

H. Taniguchi, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s783-6


3.Portal blood velocity with doppler ultrasonography in patients with chronic liver disease

M. Koda, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s787-91


4.A study of liver hemodynamics in alcoholic liver diseases
-Comparison of color doppler portal blood flow measurements and hepatic blood flow scintigraphy-

C. Koreeda, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s793-8*


5.Splenomegaly in liver cirrhosis

A. Yamaguchi, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s799-801


【discussion 1~5】

Jpn Pharmacol Ther 1999 27(Suppl.3) s803-5


6.Clinical significance of T1-weighted MRI hypertensity of globus pallidus in patients with chronic Liver disease

T. Sekiyama, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s807-12*


7.Assessment of liver cirrhosis by the magnetization transfer contrast technique in the brain of patients

M.Iwasa, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s813-5


8.Altered hepatocyte tight injection in rat model of inflammatory bowl disease

T.Kawaguchi, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s817-9


9.Altered tight junctions of hepatocytes and biliary epithelial cells in a rat model of graft-versus-host disease

K. Sasatomi, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s821-2


10.Formation of gap junction (GJ) and its biological significance in human and rat liver with hepatocellular carcinoma
-In comparison with the development of GJ during ontogenesis-

A. Muramatsu, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s823-6


【discussion 6~10】

Jpn Pharmacol Ther 1999 27(Suppl.3) s827-829


11.Gender differences of hepatic injury and cytokine production in concanavalin a induced hepatitis in mice

S.Takamoto, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s831-4


12.Nitric oxide and interleukin-10 production during endotoxemia

T. Kono, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s835-8


13.Effects of nitric oxide on the liver in vivo
-An electron spin resornance study-

T. Nakashima, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s835-8


14.Vitamin A reduces hepatic fibrosis in rats induced by dimethylnitrosamine or pig serum

I. Shimizu, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s843-8


【discussion 11~14】

Jpn Pharmacol Ther 1999 27(Suppl.3) s849-50


15.Induction if apoptotic cell death in human hepatocellular carcinoma SK-HEP-1 cells by a polyamine synthesis inhibitor, methylglyoxal bis (cyclopentylamidinohydrazone) (MGBCP)

Y. Hashimoto, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s851-2


16.Effect of cysteine on the rat cultured hepacyte
-Interation with ursodeoxycholic acud when intracellular glutathione levels were depleted-

K. Ishii, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s853-7


17.Clinical assessment of nutritional therapy using the branched chain amino acids/tyrosine ratio

N. Kawamura, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s859-61


18.Expression of vascular endthelial growth factor in hepatocyte of regenerating rat liver

E. Taniguchi, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s863-5


【discussion 15~18】

Jpn Pharmacol Ther 1999 27(Suppl.3) s867-9


19.Gene analysis of hydroxymetylbilane synthase in two Japanese families of acute intermittent porphyria-a founder Effect

Y. Horie, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s871-5*


20.A case report of idiopathic hemochromatosis without HFE gene mutations, C282Y and H63D

M. Yano, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s877-81*


21.A Japanese family with compound heterozygote of Wilson's disease gene

Y. Shiono, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s883-7*


22.Mutation analysis of a family with alagille syndrome

H.Satoh, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s889-92*


【discussion 19~22】

Jpn Pharmacol Ther 1999 27(Suppl.3) s893


23.Genetic basis of fasting hyperbilirubinemia

T. Ishihara, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s895-6


24.Heterozygous missense mutations of the bilirubin UDP-glycosyltransferase gene and the activities of the enzyme

M.Ito, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s897-9


25.A splice mutation in the human canalicular multispecific organic anion transporter gene causes Dubin-Johnson syndrome

S. Kajihara, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s901-5


26.A case of Dubin Jonson syndrome

S.Wakuzawa, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s907-8


discussion【23~26】

Jpn Pharmacol Ther 1999 27(Suppl.3) s909-10


27.A new enzymatic assay for measuring serum conjugated bilirubin and its clinical relevance

T. Ishihara, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s911-2


28.Usefulness of measuring cojugated bulirubin concentration in hepatobiliary disorders
-In comparison with total bilirubin, direct bilirubin and total bile acid concentrations-

J. Onuki, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s913-8*


29.Diagnostic criteria of Gilbert's syndrome

T. Ishihara, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s919-20


30.Different paracellular routes for bile regurgitation in primary biliary cirrhosis and primary sclerosing cholangitis

S. Sakisaka, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s921-2


discussion【27~30】

Jpn Pharmacol Ther 1999 27(Suppl.3) s923-4


31.Effect of phalloidin on fatty acid composition of hepatocyte

H. Hyogo, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s925-7


32.Effects of conjugated bile acids and BSP on biliary excretion of taurochenodeoxycholate-3-sulfate

S. Uegaki, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s929-32


33.Induction of the expression of transpoeters (Mrp3/MLP-2, P-gp) and P450 isozymes in the rat hepatocytes

K. Ogawa, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s933-40


34.The characterization of relationship between chemical structure of bile acids and recognition properties by canalicular bile acids transporter (cbat)

N. Sato, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s941-7*


35.Analysis of drug-drug interaction in biliary excretion
 -Effect of several drugs on biliary excretion of anticancer agent, irinotecan hydrochloride (CPT-11), and its active metabolite (SN-38)-

M. Horikawa, et al.

Jpn Pharmacol Ther 1999 27(Suppl.3) s949-56


discussion【31~35】

Jpn Pharmacol Ther 1999 27(Suppl.3) s957-9


【Special Lecture】

Transport of organic anions across the hepatocyte canalicular membrane

Keppler D.

Jpn Pharmacol Ther 1999 27(Suppl.3) s961-4**


Closing Remarks

Y. Adachi

Jpn Pharmacol Ther 1999 27(Suppl.3) s965