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Japanese Pharmacology & Therapeutics(JPT)

Vol. 26 Suppl. 6 1998

*All papers include English abstract

■Preclinical Studies of a NovelAcetylcholinesterase Inhibitor, Donepezil Hydrochloride

Acute toxicity study of donepezil hydrochloride in rats

F. Aruga, et al.

Jpn Pharmacol Ther 1998 26(Suppl. 6) s1157-62*


Acute toxicity study of donepezil hydrochloride in mice

F. Aruga, et al.

Jpn Pharmacol Ther 1998 26(Suppl. 6) s1163-8*


Donepezil hydrochloride toxicity study in beagle dogs on single oral administration

M. Noguchi, et al.

Jpn Pharmacol Ther 1998 26(Suppl. 6) s1169-75*


One-year oral toxicity study of donepezil hydrochloride in rats

Carol S. Auletta, et al.

Jpn Pharmacol Ther 1998 26(Suppl. 6) s1177-95*


One-year oral toxicity study of donepezil hydrochloride in dogs

Carol S. Auletta, et al.

Jpn Pharmacol Ther 1998 26(Suppl. 6) s1197-225*


Fertility study in rats treated orally with donepezil hydrochloride

T. Kawaguchi, et al.

Jpn Pharmacol Ther 1998 26(Suppl. 6) s1227-40*


Teratogenicity study in rats treated orally with donepezil hydrochloride

H. Shimazu, et al.

Jpn Pharmacol Ther 1998 26(Suppl. 6) s1241-54*


Teratogenicity study in rabbits treated orally with donepezil hydrochloride

T. Umemura, et al.

Jpn Pharmacol Ther 1998 26(Suppl. 6) s1255-61*


Perinatal and postnatal study in rats treated orally with donepezil hydrochloride

N. Niwa, et al.

Jpn Pharmacol Ther 1998 26(Suppl. 6) s1263-76*


Inhibitory effects of donepezil hydrochloride on cholinesterase activities in vitro

Y. Yamanishi, et al.

Jpn Pharmacol Ther 1998 26(Suppl. 6) s1277-82*


Inhibitory effects of orally-administered donepezil hydrochloride on cholinesterase activity in rats

Y. Yamanishi, et al.

Jpn Pharmacol Ther 1998 26(Suppl. 6) s1283-94*


Inhibitory effects of donepezil hydrochloride on cholinesterase in brain, blood and peripheral tissues of young adult rats
 ―In comparison with aged rats―

Y. Yamanishi, et al.

Jpn Pharmacol Ther 1998 26(Suppl. 6) s1295-302*


Effects of donepezil hydrochloride on the brain acetylcholine concentration in rats

T. Kosasa, et al.

Jpn Pharmacol Ther 1998 26(Suppl. 6) s1303-11*


Effects of donepezil hydrochloride on impairment of acquisition in water maze induced by medial septal lesions in rats

H. Ogura, et al.

Jpn Pharmacol Ther 1998 26(Suppl. 6) s1313-20*


General pharmacological studies on donepezil hydrochloride

H. Ono, et al.

Jpn Pharmacol Ther 1998 26(Suppl. 6) s1321-38*


Absorption, distribution, metabolism and excretion of 14C-donepezil hydrochloride after a single oral administration to rats

K. Matui, et al.

Jpn Pharmacol Ther 1998 26(Suppl. 6) s1339-55*


Absorption, distribution, metabolism and excretion of 14C-donepezil hydrochloride after a single oral administration to beagle dogs

K. Matui, et al.

Jpn Pharmacol Ther 1998 26(Suppl. 6) s1357-71*


Tissue distribution of 14C-donepezil hydrochloride after a single oral administration to male rats by autoradiography

K. Matui, et al.

Jpn Pharmacol Ther 1998 26(Suppl. 6) s1373-8*


The secretion into the milk of nursing rats and tissue distribution in pregnant rats of 14C-donepezil hydrochloride after a single oral administration

Jpn Pharmacol Ther 1998 26(Suppl. 6) s1379-90*